Mass Spectrometry Edmond de Hoffmann Universit´e Catholique de Louvain, Belgium & Ludwig Institute for Cancer Research, Brussels, Belgium Vincent Stroobant Ludwig Institute for Cancer Research, Brussels, Belgium
Mass Spectrometry Edmond de Hoffmann Universit´e Catholique de Louvain, Belgium & Ludwig Institute for Cancer Research, Brussels, Belgium Vincent Stroobant Ludwig Institute for Cancer Research, Brussels, Belgium
Preface Introduction Principles Diagram of a Mass Spectrometer History Ion Free Path 1 Ion Sources 1.1 Electron Ionization 1.2 Chemical Ionization 1.3 Field Ionization 1.4 Fast Atom Bombardment and Liquid Secondary Ion Mass Spectrometry 1.5 Field Desorption 1.6 Plasma Desorption 1.7 Laser Desorption 1.8 Matrix-Assisted Laser Desorption Ionization 1.9 Thermospray 1.10 Atmospheric Pressure Ionization 1.11 Electrospray 1.12 Atmospheric Pressure Chemical Ionization 1.13 Atmospheric Pressure Photoionization 1.14 Atmospheric Pressure Secondary Ion Mass Spectrometry 1.15 Inorganic Ionization Sources 1.16 Gas-Phase Ion-Molecule Reactions 1.17 Formation and Fragmentation of Ions: Basic Rules
2 Mass Analysers 2.1 Quadrupole Analysers 2.2 Ion Trap Analysers 2.3 The Electrostatic Trap or ‘Orbitrap’ 2.4 Time-of-Flight Analysers 2.5 Magnetic and Electromagnetic Analysers 2.6 Ion Cyclotron Resonance and Fourier Transform Mass Spectrometry 2.7 Hybrid Instruments 3 Detectors and Computers 3.1 Detectors 3.2 Computers 4 Tandem Mass Spectrometry 4.1 Tandem Mass Spectrometry in Space or in Time 4.2 Tandem Mass Spectrometry Scan Modes 4.3 Collision-Activated Decomposition or Collision-Induced Dissociation 4.4 Other Methods of Ion Activation 4.5 Reactions Studied in MS/MS 4.6 Tandem Mass Spectrometry Applications 5 Mass Spectrometry/Chromatography Coupling 5.1 Elution Chromatography Coupling Techniques 5.2 Chromatography Data Acquisition Modes 5.3 Data Recording and Treatment 6 Analytical Information 7 Fragmentation Reactions 8 Analysis of Biomolecules