目录: 1 Overview Drug Metabolism in the Modern Pharmaceutical Industry 2 Oxidative, Reductive, and Hydrolytic Metabolism of Drugs 3 Conjugative Metabolism of Drugs 4 Enzyme Kinetics 5 Metabolism-Mediated Drug-Drug Interactions 6 Drug Transporters in Drug Disposition, Drug Interactions, and Drug Resistance 7 Regulatory Considerations of Drug Metabolism and Drug Interaction Studies 8 Drug Metabolism Research as an Integral Part of the Drug Discovery Process 9 Role of Drug Metabolism in Drug Development 10 Applications of Liquid Radiochromatography Techniques in Drug Metabolism Studies 11 Application of Liquid Chromatography Mass Spectrometry for Metabolite Identification 12 Introduction to NMR and Its Application in Metabolite Structure Determination 13 Determination of Metabolic Rates and Enzyme Kinetics 14 Protocols for Assessment of In vitro and In vivo Bioactivation Potential of Drug Candidates 15 Reaction Phenotyping 16 Analysis of In vitro Cytochrome P450 Inhibition in Drug Discovery and Development 17 Testing Drug Candidates for CYP3A4 Induction 18 ADME Studies in Animals and Humans Experimental Design, Metabolite Profiling and Identification, and Data Presentation