1 Binding of nonsteroidal anti-inflammatory agents to proteins—I. Ibuprofen-serum albumin interaction
John B. Whitlam, Michael J. Crooks, Kenneth F. Brown and Peter Veng Pedrrsen
Department of Pharmacy, University of Sydney, Sydney, N.S.W. 2006, Australia
Received 2 March 1978; accepted 20 June 1978. ; Available online 15 November 2002 Biochemical Pharmacology Volume 28, Issue 5 , 1 March 1979, Pages 675-678
2 Enhanced albumin protein separations and protein—drug binding constant measurements using anti-inflammatory drugs as run buffer additives in affinity capillary electrophoresis
Peng Sun, Alexandra Hoops and Richard A. Hartwick
Department of Chemistry, State University of New York at Binghamton Binghamton, NY 13902, USA
Received 14 June 1994; revised 16 August 1994. Available online 26 February 2002 Journal of Chromatography B: Biomedical Sciences and Applications Volume 661, Issue 2 , 18 November 1994, Pages 335-340
我只能查到第二篇的摘要 Enhanced albumin protein separations and protein-drug binding constant measurements using anti-inflammatory drugs as run buffer additives in affinity capillary electrophoresis.Sun P, Hoops A, Hartwick RA. Department of Chemistry, State University of New York at Binghamton 13902.
An affinity capillary electrophoresis (ACE) method for improving albumin protein separations has been developed. Separation efficiencies for bovine serum albumin (BSA) and human serum albumin (HSA) are dramatically improved by using anti-inflammatory compounds as run buffer additives. The anti-inflammatory drugs used as biospecific ligands to improve the protein separation include ibuprofen (IB), flurbiprofen (FL), and ketoprofen (KE). The binding constants of proteins (BSA and HSA) for the anti-inflammatory ligands (FL and IB) are estimated by ACE and compared to literature values.
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