原文由 loudpan 发表:
甲基汞毒理学的英文版好书.
氯化甲基汞对不同发育阶段大鼠脑组织c-Jun表达的影响
Effects of chloride methyl mercury on c-Jun expression of rat brain at different developing time
董丽波 李志超 毕晓颖 许传杰 郭丽
摘 要:目的:探讨氯化甲基汞(MMC)对发育脑组织损伤的机理.方法:将Wistar系妊娠大鼠于妊娠7~10d连续灌胃给予MMC4mg/kg,取P1(postnatalday1),3,5,7,10,15仔鼠脑组织制备常规组织切片,采用免疫组织化学法检测c-Jun表达.结果:对照组发育阶段仔鼠大、小脑有c-Jun表达.随着出生后时间延长,大、小脑c-Jun阳性细胞数下降,并且c-Jun阳性细胞具有典型凋亡形态.实验组c-Jun表达有高于对照组的趋势,其中P7,10,15小脑中c-Jun表达明显高于对照组(P<0.05).结论:c-Jun参与了脑细胞发育中正常的凋亡过程.MMC诱导大鼠脑发育中神经细胞凋亡,可能是通过c-Jun表达实现的.
关键词:甲基汞;发育脑;c-Jun;凋亡
分类号:R99;R-332 文献标识码:A
文章编号:0253-3707(2000)05-0460-03
基金项目:国家自然科学基金资助课题(3970655)
作者简介:董丽波(1973-),女,吉林省辽源市人,助教,医学硕士,主要从事甲基汞毒理学研究.
作者单位:董丽波(中国预防科学院)
李志超(预防医学院毒理学教研室吉林长春 130021)
毕晓颖(预防医学院毒理学教研室吉林长春 130021)
许传杰(预防医学院毒理学教研室吉林长春 130021)
郭丽(预防医学院毒理学教研室吉林长春 130021)
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