Abstract of CN1724526 The invention provides a method for synthesis of ranitidine alkali and ranitidine hydrochloride. It is characterized in that: 2- [ [ [5- (dimethylamino) methyl- 2- furyl] methyl] sulpho] ethylamine reacts with 1- methylthio - 1- methylamino- 2- nitro ethylene directly in water phase, crystallizing and separating out ranitidine alkali. The synthesis method comprises the following steps: adding 2- [ [ [5- (dimethylamino) methyl- 2- furyl] methyl] sulpho] ethylamine and 1- methylthio- 1- methylamino- 2- nitro ethylene with a molar ratio of 1.04: 1 into water, heating to 48- 52 Deg. C, reacting 4.5 hours with a vacuum degree of 0.02- 0.05 MPa, cooling, adding sodium-hydroxide of concentration of 10% to regulate the PH value to 11.0- 11.4, filtrating and cooling the filtrate to 0- 2 Deg. C, crystallizing for 12 hours, centrifugally filtrating, and rinsing filter cake with purity water to prepare wet ranitidine alkali; dissolving ranitidine alkali in alcohol and reacting with chlorhydric acid to prepare ranitidine hydrochloride. ________________________________________ Data supplied from the esp@cenet database - Worldwide