Solid-state carbon NMR 可以定量,请看下面的文章.该文研究的是一种药物roxifiban,我把它的结构也帖出来供参考. Title Solid-state carbon NMR characterization of the polymorphs of roxifiban Author(s) Vickery, R.D., Nemeth, G.A., Maurin, M.B., Journal Journal of Pharmaceutical and Biomedical Analysis Vol. 30, No. 1, pages 125-129 (2002) ISSN 0731-7085 Publisher Elsevier Abstract Roxifiban, an experimental antithrombotic prodrug, exists as crystalline forms I and II. A quantitative solid-state nuclear magnetic resonance (NMR) method was developed to characterize the two polymorphs of roxifiban. The differences in the NMR spectra of the polymorphs were utilized in analyses of physical blends of the pure crystalline forms to establish a calibration curve. A detection limit of 9% form II in form I was determined from analysis of a 10% form II blend. Solid-state NMR was a valuable technique to quantify the polymorphic purity of roxifiban where other techniques such as differential scanning calorimetry (DSC) could not be used for this purpose.
Solid-state carbon NMR 可以定量,请看下面的文章.该文研究的是一种药物roxifiban,我把它的结构也帖出来供参考. Title Solid-state carbon NMR characterization of the polymorphs of roxifiban Author(s) Vickery, R.D., Nemeth, G.A., Maurin, M.B., Journal Journal of Pharmaceutical and Biomedical Analysis Vol. 30, No. 1, pages 125-129 (2002) ISSN 0731-7085 Publisher Elsevier Abstract Roxifiban, an experimental antithrombotic prodrug, exists as crystalline forms I and II. A quantitative solid-state nuclear magnetic resonance (NMR) method was developed to characterize the two polymorphs of roxifiban. The differences in the NMR spectra of the polymorphs were utilized in analyses of physical blends of the pure crystalline forms to establish a calibration curve. A detection limit of 9% form II in form I was determined from analysis of a 10% form II blend. Solid-state NMR was a valuable technique to quantify the polymorphic purity of roxifiban where other techniques such as differential scanning calorimetry (DSC) could not be used for this purpose.
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