Bioelectronics－From Theory to Applications 这是一本与生物芯片非常相关的书，你总会在其中发现你感兴趣的内容！有了它，你可以向世界最前沿的技术学习！
Edited by：Itamar Willner and Eugenii Katz
下面是本书的目录，为了不致造成大家认识上的混乱，我没有自作聪明地给出中文翻译，呵呵，也没这个能力 第一章 Bioelectronics – An Introduction 第二章 Electron Transfer Through Proteins 2.1 Electronic Energy Landscapes 15 2.2 Theory of Electron Tunneling 15 2.3 Tunneling Pathways 17 2.4 Coupling-limited ET Rates and Tests of the Pathway Model 19 2.5 Multiple Tunneling Pathway Models 23 2.6 Interprotein Electron Transfer: Docking and Tunneling 27 2.7 Some New Directions in Electron Transfer Theory and Experiment 28 2.8 Concluding Remarks 31 第三章 Reconstituted Redox Enzymes on Electrodes: From Fundamental Understanding of Electron Transfer at Functionalized Electrode Interfaces to Biosensor and Biofuel Cell Applications 3.1 Introduction 35 3.2 Electrodes Functionalized with Reconstituted Redox Proteins 43 3.2.1 Reconstituted Flavoenzyme-Electrodes Using Molecular or Polymer Relay Systems 43 3.2.2 Electrical Contacting of Flavoenzymes by Reconstitution on Carbon Nanotubes and Conducting Polymer Wires 53 3.2.3 Electrical Contacting of Flavoenzymes by Means of Metallic Nanoparticles 57 3.2.4 Integrated Electrically Contacted Electrodes Composed of Reconstituted Quinoproteins 65 3.2.5 Reconstituted Electrically Contacted Hemoproteins 67 3.2.6 Reconstituted de novo Hemoproteins on Electrodes 69 3.3 Electrical Contacting of Redox Proteins by Cross-linking of Cofactor-Enzyme Affinity Complexes on Surfaces 73 3.3.1 Integrated NAD(P)+-Dependent Enzyme-Electrodes 73 3.3.2 Integrated Electrically Contacted Hemoprotein Electrodes 80 3.4 Reconstituted Enzyme-Electrodes for Biofuel Cell Design 83 3.5 Conclusions and Perspectives 91 References 93 第四章 Application of Electrically Contacted Enzymes for Biosensors 4.1 Introduction 99 4.2 Biosensors – Precursors of Bioelectronics 99 4.3 Via Miniaturization to Sensor Arrays – The Biochip 102 4.4 The Route to Electrically Contacted Enzymes in Biosensors 104 4.5 Routine Applications of Enzyme Electrodes 107 4.6 Research Applications of Directly Contacted Proteins 109 4.6.1 Protein Electrodes for the Detection of Oxygen-derived Radicals 109 4.6.2 Cytochrome P 450 – An Enzyme Family Capable of Direct Electrical Communication 117 4.7 Conclusions 123 References 123 第五章 Electrochemical DNA Sensors 5.1 Introduction 127 5.1.1 Indicator Electrodes 128 5.1.2 Electrochemical Methods 128 5.2 Natural Electroactivity and Labeling of Nucleic Acids 129 5.2.1 Electroactivity of Nucleic Acid Components 129 5.2.2 Analysis of Unlabeled Nucleic Acids 131 5.2.3 Electroactive Labels of Nucleic Acids 136 5.2.4 Signal Amplification 140 5.3 Sensors for DNA and RNA Hybridization 140 5.3.1 DNA Hybridization 142 第六章 Probing Biomaterials on Surfaces at the Single Molecule Level for Bioelectronics 6.1 Methods for Achieving Controlled Adsorption of Biomolecules 194 6.2 Methods for Investigating Adsorbed Biomolecules 195 6.3 Surfaces Patterned with Biomolecules 197 6.4 Attempts at Addressing Single Biomolecules 201 6.5 Conclusions 205 References 207
第七章 Interfacing Biological Molecules with Group IV Semiconductors for Bioelectronic Sensing 7.1 Introduction 209 7.2 Semiconductor Substrates for Bioelectronics 210 7.2.1 Silicon 210 7.2.2 Diamond 211 7.3 Chemical Functionalization 213 7.3.1 Covalent Attachment of Biomolecules to Silicon Surfaces 213 7.3.2 Hybridization of DNA at DNA-modified Silicon Surfaces 215 7.3.3 Covalent Attachment and Hybridization of DNA at Diamond Surfaces 217 7.4 Electrical Characterization of DNA-modified Surfaces 219 7.4.1 Silicon 219 7.4.2 Impedance Spectroscopy of DNA-modified Diamond Surfaces 225 7.5 Extension to Antibody–Antigen Detection 225 7.6 Summary 227 References 228 第八章 Biomaterial-nanoparticle Hybrid Systems for Sensing and Electronic Devices 8.1 Introduction 231 8.2 Biomaterial–nanoparticle Systems for Bioelectrochemical Applications 232 8.2.1 Bioelectrochemical Systems Based on Nanoparticle-enzyme Hybrids 232 8.2.2 Electroanalytical Systems for Sensing of Biorecognition Events Based on Nanoparticles 235 8.3 Application of Redox-functionalized Magnetic Particles for Triggering and Enhancement of Electrocatalytic and Bioelectrocatalytic Processes 250 8.4 Conclusions and Perspectives 259 References 261 第九章 DNA-templated Electronics 9.1 Introduction and Background 265 9.2 DNA-templated Electronics 266 9.3 DNA Metallization 268 9.4 Sequence-specific Molecular Lithography 271 9.5 Self-assembly of a DNA-templated Carbon Nanotube Field-effect Transistor 276 9.6 Summary and Perspective 279 References 284 第十章 Single Biomolecule Manipulation for Bioelectronics 10.1 Single Molecule Manipulation 287 10.1.1 Glass Microneedle 289 10.1.2 Laser Trap 289 10.1.3 Space and Time Resolution of Nanometry 290 10.1.4 Molecular Glues 291 10.1.5 Comparisons of the Microneedle and Laser Trap Methods 291 10.2 Mechanical Properties of Biomolecules 291 10.2.1 Protein Polymers 291 10.2.2 Mechanically Induced Unfolding of Single Protein Molecules 294 10.2.3 Interacting Molecules 296 10.3 Manipulation and Molecular Motors 297 10.3.1 Manipulation of Actin Filaments 298 10.3.2 Manipulation of a Single Myosin Molecule 300 10.3.3 Unitary Steps of Myosin 300 10.3.4 Step Size and Unconventional Myosin 302 10.3.5 Manipulation of Kinesin 303 10.4 Different Types of Molecular Motors 304 10.5 Direct Measurements of the Interaction Forces 304 10.5.1 Electrostatic Force Between Positively Charged Surfaces 305 10.5.2 Surface Force Property of Myosin Filaments 305 References 306 第十一章 Molecular Optobioelectronics 11.1 Introduction 309 11.2 Electronically Transduced Photochemical Switching of Redox-enzyme Biocatalytic Reactions 310 11.2.1 Electronic Transduction of Biocatalytic Reactions Using Redox Enzymes Modified with Photoisomerizable Units 312 11.2.2 Electronic Transduction of Biocatalytic Reactions Using Interactions of Redox Enzymes with Photoisomerizable ‘‘Command Interfaces’’ 316 11.2.3 Electronic Transduction of Biocatalytic Reactions of Redox Enzymes Using Electron Transfer Mediators with Covalently Bound Photoisomerizable Units 322 11.3 Electronically Transduced Reversible Bioaffinity Interactions at Photoisomerizable Interfaces 323 11.3.1 Reversible Immunosensors Based on Photoisomerizable Antigens 326 11.3.2 Biphasic Reversible Switch Based on Bioaffinity Recognition vents Coupled to a Biocatalytic Reaction 330 11.4 Photocurrent Generation as a Transduction Means for iocatalytic and Biorecognition Processes 332 11.4.1 Enzyme-Biocatalyzed Reactions Coupled to Photoinduced Electron Transfer Processes 332 11.4.2 Biorecognition Events Coupled to Photoinduced Electron ransfer Processes 334 11.5 Conclusions 335 References 336 第十二章 The Neuron-semiconductor Interface 12.1 Introduction 339 12.2 Ionic–Electronic Interface 340 12.2.1 Planar Core-coat Conductor 343 12.2.2 Cleft of Cell-silicon Junction 346 12.2.3 Conductance of the Cleft 349 12.2.4 Ion Channels in Cell-silicon Junction 358 12.3 Neuron–Silicon Circuits 362 12.3.1 Transistor Recording of Neuronal Activity 362 12.3.2 Capacitive Stimulation of Neuronal Activity 367 12.3.3 Two Neurons on Silicon Chip 372 12.3.4 Toward Defined Neuronal Nets 377 12.4 Brain–Silicon Chips 383 12.4.1 Tissue-sheet Conductor 383 12.4.2 Transistor Recording of Brain Slice 385 12.4.3 Capacitive Stimulation of Brain Slices 388 12.5 Summary and Outlook 392 References 393 第十三章 S-Layer Proteins in Bioelectronic Applications 13.1 Introduction 395 13.1.1 Upcoming Nanotechnology Applications 396 13.2 S-layer Proteins and Porins 396 13.2.1 The Building Principles of Tailored S-layer Proteins Layers 397 13.2.2 Chemical Modification of S-layers 400 13.2.3 Interaction by Noncovalent Forces 401 13.3 Experimental Methods Developed for Hybrid Bioelectronic Systems 402 13.3.1 Electron Microscopy 402 13.3.2 Combined X-Ray and Neutron Reflectometry 402 13.3.3 Atomic Force Microscopy Using Protein-functionalized AFM-cantilever Tips 403 13.3.4 Scanning Electrochemical Microscopy 404 13.4 Applications of S-layer Proteins at Surfaces 404 13.4.1 S-layer Proteins as Permeability Barriers 404 13.4.2 S-layer Proteins at Lipid Interfaces 405 13.4.3 Introduction of Supramolecular Binding Sites into S-layer Lattices 412 13.5 Molecular Nanotechnology Using S-layers 414 13.5.1 Patterning of S-layer Lattices by Deep Ultraviolet Irradiation (DUV) 414 13.5.2 Synthesis of Semiconductor and Metal Nanoparticles Using S-layer Templates Design of Gold and Platinum Superlattices Using the Crystalline Surfaces Formed by the S-layer Protein of Bacillus sphaericus as a Biotemplate 416 13.5.3 Generation of S-layer Lattice-supported Platinum Nanoclusters 418 13.5.4 Formation and Selective Metallization of Protein Tubes Formed by the S-layer Protein of Bacillus sphaericus NCTC 9602 419 13.5.5 S-layer/Cadmium Sulfide Superlattices 421 13.6 Immobilization and Electrochemical Conducting of Enzymes in S-layer Lattices 421 13.6.1 S-layer and Glucose Oxidase-based Amperometric Biosensors 421 13.6.2 S-layer and Glucose Oxidase–based Optical Biosensors 422 13.7 Conclusions 423 References 423 第十四章 Computing with Nucleic Acids 14.1 Introduction 427 14.2 Massively Parallel Approaches 428 14.3 The Seeman–Winfree Paradigm: Molecular Self-assembly 435 14.4 The Rothemund–Shapiro Paradigm: Simulating State Machines 439 14.5 Nucleic Acid Catalysts in Computation 442 14.6 Conclusion 453 References 454 第十五章 Conclusions and Perspectives
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