原文由 shelby 发表:
Sorry I couldn't type in Chinese here. I'm working on detection of multiple drugs(8) simutaneously by LC/MS/MS, the baselines for them are not identical. What's the possible reasons and how to optimize? Can I go ahead to do quantification with their very own baseline? Thanks a lot! BTW, how to 结贴? Not only the instrument but also 论坛 is brand new for me.
不同的化合物基线噪音不一样!
刚优化完化合物质谱条件建议冲洗柱子和仪器1-2天再开始做实验。这样基线会降很多。
串联质谱很灵敏,所以要注意防止样品污染,样品处理过程要处处想着防止污染的问题。最重要的是如果条件许可的话,样品的称量和样品预处理室要分开。我们以前没分开,三天两头有污染。