可以尝试一下以下条件,盐酸二甲双胍的保留时间不是很长。
Method ConditionsColumn | Cogent Diamond Hydride™, 4µm, 100A |
Catalog No. | 70000-15P-2 |
Dimensions | 2.1 x 150 mm |
Solvents | A: | 50% isopropanol/ 50% DI water/ 0.1% acetic acid | B: | Acetonitrile/ 0.1% acetic acid |
|
Gradient | time (min.) | %B | time (min.) | %B | 0 | 100 | 9 | 20 | 2 | 100 | 10 | 100 | 5 | 20 | | |
|
Post Time | 5 min |
Injection Vol. | 1 microL |
Flow rate | 0.4 mL/min. |
Detection | ESI � POS - Agilent 6210 MSD TOF mass spectrometer |
Peak | 1. Cyanoguanidine 85.0509 m/z (M +H)+ 2. Melamine 127.0727 m/z (M +H)+ 3. Metformin 130.1087 m/z (M +H)+ |
t0 | 0.9 min |
http://www.microsolvtech.com/hplc/app_metformin.asp