【Author】 ZHOU Jian-ke YANG Dong-xia XU Peng GENG Xiang-fei(Research center of physics and chemistry analysis,key laboratory of analytical science and technology of Hebei Province,Hebei University,Baoding 071002,China)
【Abstract】 A solid phase dispersion extraction-high performance liquid chromatography was used for the determination of dimethyl fumarate(DMF)in bean paste.Anhydrous sodium sulfate was used as dispersant and dehydrant.DMF was analyzed by Diamonsil C18 column using UV detector at 220 nm.The mobile phase composed of a mixture of methanol and water(55∶45,V/V),with the flow rate of 1.0 mL /min.The column temperature was 25℃.The linear range was 0.136 μg /mL～33.5 μg /mL with correlation coefficient of 0.999 8.T... 更多还原 【关键词】 固相分散萃取； 高效液相色谱； 富马酸二甲酯； 【Key words】 solid phase dispersion extractin； liquid chromatography； dimethyl fumarate
【Author】 ZHOU Jian-ke** LIU Rui-ying LANG Yu-miao(Hebei University Physical Testing and Chemical Analysis Center,Hebei Province Key Laboratory of Analytical Science and Technology,Baoding,071002)
【Abstract】 BHA and TBHQ in fried foods were deter-mined by reverse-phase liquid chromatography with MeOH/CH2Cl(2v/v,9:1)extracted.They were analyzed by Diamonsil C18 column using UV detector at 280nm,the mobile phase was 80 % methanol and the column oven was room temperature.The methodology exhibited good linearity between 0.1 and 100.0 mg/L with corre-lation coefficient of 0.9999.The limits of detection were 0.1μg/g,the average recoveries were above 80 %.TB-HQ was detected in fried chicken roll,but not ex... 更多还原 【关键词】 叔丁基对羟基茴香醚； 特丁基对苯二酚； 反相高效液相色谱法； 油炸食品； 【Key words】 BHA； TBHQ； RP-HPLC； fried food； 【基金】 国家计量基标准(化学部分)资源共享平台建设项目(NO:2005DKA10800)。
【Abstract】 Objective To improve the content determination method of compound dexamethasone cream.Methods The compound dexamethasone cream was assayed by HPLC of external standard method,the diamonsil ODS column was used with methanol-water(70∶30)as mobile phase,the detective wavelength was 240 nm.Results The linear range of dexamethasone was 5.2~38.7 μg/mL,the average recovery rate was 99.85%(the RSD was 1.7%,n=6).Conclusion The improved method is simple and rapid with good specificity.It is suitable for p... 更多还原 【关键词】 复方醋酸地塞米松乳膏； 外标法； 含量测定； 【Key words】 Compound dexamethasone cream； External standard method； Content determination；
【Author】 SONG Min1,JIA Yu-rong2,TONG Li-jin2,SUN Li-xin2(1.Dalian Food and Drug Administration,Dalian 116021,China;2.College of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China)
【Abstract】 Objective To establish a RP-HPLC method for the determination of daidzin in Solanum lyratum Thunb.Methods A Diamonsil C18 column(250 mm × 4.6 mm,5 μm) was used.The mobile phase consisted of ace-tonitrile-water-phosphoric acid(16∶ 84∶ 0.1,v /v).The wavelength was set at 260 nm.Results The linear range ofdaidzin was 1.0 ～ 40.0 μg /mL.The average recovery was 100.1%(RSD was 1.1%).Conclusion The method issimple,accurate,reproducible,and it could be used for the quality control of Solanum lyratum Thu... 更多还原 【关键词】 白英； 大豆苷； 反相高效液相色谱法； 含量测定； 【Key words】 Solanum lyratum Thunb； Daidzin； RP-HPLC； Determination； 【基金】 辽宁省科技厅资助项目(2007226011);沈阳市科技局攻关项目(1071164-9-00)
【Abstract】 Objective To develop a RP-HPLC gradient elution method for determination of dimmer ampicillin in ampicillin sodium and sulbactam sodium for injection.Methods The analytical column was C18 column(250 mm ×4.6 mm,5 μm),the mobile phase was A[12% acetic acid-0.2 mol/L potassium dihydrogen phosphate-acetonitrile-water(0.5:50:50:900) ]and B[12% acetic acid -0.2 mol/L potassium dihydrogen phosphate-acetonitrile-water(0.5∶50:400:550)](initial ratio of A was 85% for 8.5 min,then decreasing to 0 in 30 min... 更多还原 【关键词】 聚合物； HPLC； 氨苄西林二聚物； 【Key words】 Polymers； High-performance liquid chromatography； Dimmer ampicillin；
【Author】 YANG Yan-yun1,CHEN Lian-geng2,YANG Li-bo3 (1.School of Pharmacy,Liaoning University of Traditional Chinese Medicine,Dalian 116600,China;2.Supple and Sales Company,North-east Pharmaceutical Group Co.Ltd,Shenyang 110021,China;3.Huludao City Medicine Co.Ltd,Huludao 125300,China)
【Abstract】 Objective To develop a simple,sensitive and rapid method for the determination of dipyridamolein rats plasma.Methods The plasma concentration of dipyridamole was determined by RP-HPLC method,the analysis involved a 200 mm×4.6 mm column packed with C18 (5 μm),the mobile phase consisted of methyl alcohol-pH 6.5 potassium dihydrogen phosphate buffer (60∶40).Results A good linearity was obtained in the range of 0.10~10.0 μg/mL(r=0.997),the recovery was between 84.3%~92.3%,the accuracy was between 99... 更多还原 【关键词】 双嘧达莫； 大鼠血浆； RP-HPLC； 【Key words】 Dipyridamole； Rats plasma； RP-HPLC；
【Author】 JIN Yan1,ZHENG Yun-hua2,LU Yan-qing3,ZHAO Tie1,DUAN Xu1(1.Department of Pharmacy,Shengjing Hospital of China Medical University,Shenyang 110004,China;2.Liaoning Medicine Corporation,Shenyang 110001,China;3.Liaoning Zhongjian New Pharmaceutical Agency Co.,Ltd,Shenyang 110021,China)
【Abstract】 Objective To establish a high performance liquid chromatographic method for the determination of ketamine hydrochloride in rabbit plasma.MethodsThe analytical column was Diamonsil C18(200 mm×4.6 mm,5 μm).The mobile phase was methanol-water(50∶50)at a flow rate of 1.0 mL/min,and the detective wavelength was 275 nm.Plasma was precipitated with perchloric acid,and phenacetin was used as internal standard.Plasma concentrations of ketamine hydrochloride and internal standard were determined by HPLC.R... 更多还原 【关键词】 盐酸氯胺酮； 非那西丁； 高效液相色谱法； 【Key words】 Ketamine Hydrochloride； Phenacetin； HPLC；
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