主题：【讨论】请问在色谱分析的方法学评价中Selectivity 和Specificity 区别是什么？

谢谢，
下面是英文解释，

但是我还是没弄清楚具体区别是什么，

尤其是在药物残留方面

The  term  selectivity  is  often  confused  and  incorrectly
used with  the  term specificity, especially  in  the  field of
chromatographic  analytical  methods. 


Selectivity:  the  selectivity  of  an  assay  is  a measure  of
the extent  to which  the method can determine a parti-
cular compound in the analysed matrices without inter-
ference from matrix components. A method that is per-
fectly  selective  for  an  analyte  or  group  of  analytes  is
specific。
Specificity: the validation procedure should confirm the
ability of  the method  to unequivocally  assess  the  ana-
lyte  in  the presence of other  components  that may be
present  (for example,  impurities, degradation products
and  matrix  components).  The  necessary  validation
studies depend on the method’s use. Lack of specificity
of  an  individual  analytical procedure may be  compen-
sated  by  other  supporting  analytical  procedures  [2].
This  definition  from  the  International  Conference  on
Harmonization  (ICH)  is  restricted  to pharmaceuticals,
including active substances and formulations. However,
in  the  fields of bioanalysis  (analysis of analytes  in bio-
logical matrices and  in bioavailability  studies)  the  spe-
cificity  is completely neglected.