主题：【讨论】三聚氰胺过后就是三聚氰酸！

楼主说的两者的混合作用应该和农药混合使用后的毒力表现类似吧，农药混合后对生物的作用可以分为三种：相加作用、增效作用、拮抗作用。现在不知道三聚氰酸和三聚氰胺的混合的毒力和毒理是怎么样的？

三聚氰酸的环境数据：
CAS Number : 000108-80-5
Chem Name  : CYANURIC ACID
Mol Formula: C3H3N3O3
Mol Weight : 129.08
Melting Pt : 360 deg C
Boiling Pt :
Water Solubility:
  Value : 2000 mg/L 
Temp  : 25 deg C 
Type  : EXP 
Ref  : BURAKEVICH,JV (1979)
Log P (octanol-water): 
Value : 0.61 
Type  : EST 
Ref  : MEYLAN,WM & HOWARD,PH (1995)
Vapor Pressure: 
Value : 3.05E-008 mm Hg 
Temp  : 25 deg C 
Type  : EST 
Ref  : MPBPVP
pKa Dissociation Constant: 
Value : 7.2 
Temp  : 
Type  : EXP 
Ref  : BUDAVARI,S ET AL. (1989)
Henry's Law Constant: 
Value : 1.36E-018 atm-m3/mole 
Temp  : 25 deg C 
Type  : EST 
Ref  : MEYLAN,WM & HOWARD,PH (1991)
Atmospheric OH Rate Constant: 
Value : 4.69E-013 cm3/molecule-sec 
Temp  : 25 deg C 
Type  : EST 
Ref  : MEYLAN,WM & HOWARD,PH (1993)

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原文由 pingguwu 发表:
三聚氰胺热过了，对于检测人员忙了一阵子，本人9月11日就向上回报样品中有三聚氰酸，来自何处有待考证，当三聚氰胺已经够麻烦了，因此没有人理睬，不过本人肯定凭三聚氰胺不足以死人，一定是三聚氰胺和三聚氰酸的共同作用，现在国家很多部门在研究三聚氰酸的测定方法，当三聚氰酸比三聚氰胺难做，我想下个热点就是三聚氰酸！

哎呀，最近三聚氰胺把我做得头大呀，每天都得处理一批，看到pingguwu老师说到三聚氰酸，不知您摸索出来方法了没有？

这种物质国内外研究的不多，没有什么可靠性数据。产生三聚氰酸后，下一步会生成什么毒害物质也是要研究的吧。

三聚氰胺水解后会产生三聚氰酸,一酰胺,二酰胺,衍生后用GC-MS都可以测试的,只是液态奶不太好测.
三聚氰酸也能用LC-MS测试.

原文由 hotdoglet 发表:
三聚氰酸的环境数据：
CAS Number : 000108-80-5
Chem Name  : CYANURIC ACID
Mol Formula: C3H3N3O3
Mol Weight : 129.08
Melting Pt : 360 deg C
Boiling Pt :
Water Solubility:
  Value : 2000 mg/L 
Temp  : 25 deg C 
Type  : EXP 
Ref  : BURAKEVICH,JV (1979)
Log P (octanol-water): 
Value : 0.61 
Type  : EST 
Ref  : MEYLAN,WM & HOWARD,PH (1995)
Vapor Pressure: 
Value : 3.05E-008 mm Hg 
Temp  : 25 deg C 
Type  : EST 
Ref  : MPBPVP
pKa Dissociation Constant: 
Value : 7.2 
Temp  : 
Type  : EXP 
Ref  : BUDAVARI,S ET AL. (1989)
Henry's Law Constant: 
Value : 1.36E-018 atm-m3/mole 
Temp  : 25 deg C 
Type  : EST 
Ref  : MEYLAN,WM & HOWARD,PH (1991)
Atmospheric OH Rate Constant: 
Value : 4.69E-013 cm3/molecule-sec 
Temp  : 25 deg C 
Type  : EST 
Ref  : MEYLAN,WM & HOWARD,PH (1993)

这些是理化性质，而非毒理数据

三聚氰酸】(cyanuric acid)
学名“2，4，6-三羟基-1，3，5-三嗪”。化学式，分子量129.08。白色结晶，通常含有二分子结晶水，露于空气中会失去结晶水。但从浓HCl或浓中沉淀出来的产物为无水物。性质安定，在550℃时仍不分解，强烈则分解成氰酸（实验室来源）。较易溶于热水，溶于热乙醇、吡啶、浓盐酸及浓硫酸，不溶于冷甲醇、乙醚、丙酮、苯及氯仿。通常以尿素为原料直接加热或在无水存在下加热，首先形成缩二脲，继续强热脱氨形成三聚氰酸。三聚氰酸可用以制造三聚氰胺、海绵状橡胶、除草剂，也是制备*三聚氰氯的中间体。


这个产品资料还真是不是很好找。
尤其是毒理的，数据都不太一样

氰尿酸三聚氰胺，在水中溶解度远远小于氰尿酸 （三聚氰酸）和三聚氰胺的，会不会这就是产生结石的原因？
两者是有协同作用，据附件中所述。
gg

Assessment of melamine and cyanuric acid toxicity in cats
Birgit Puschner1, Robert H. Poppenga, Linda J. Lowenstine, Michael S. Filigenzi and Patricia A. Pesavento
Correspondence: 1Corresponding Author: Birgit Puschner, California Animal Health and Food Safety Laboratory System, Toxicology Laboratory, University of California, West Health Science Drive, Davis, CA, e-mail: bpuschner@ucdavis.edu

The major pet food recall associated with acute renal failure in dogs and cats focused initially on melamine as the suspect toxicant. In the course of the investigation, cyanuric acid was identified in addition to melamine in the offending food. The purpose of this study was to characterize the toxicity potential of melamine, cyanuric acid, and a combination of melamine and cyanuric acid in cats. In this pilot study, melamine was added to the diet of 2 cats at 0.5% and 1%, respectively. Cyanuric acid was added to the diet of 1 cat at increasing doses of 0.2%, 0.5%, and 1% over the course of 10 days. Melamine and cyanuric acid were administered together at 0%, 0.2%, 0.5%, and 1% to 1 cat per dose group. No effect on renal function was observed in cats fed with melamine or cyanuric acid alone. Cats dosed with a combination were euthanized at 48 hours after dosing because of acute renal failure. Urine and touch impressions of kidneys from all cats dosed with the combination revealed the presence of fan-shaped, birefringent crystals. Histopathologic findings were limited to the kidneys and included crystals primarily within tubules of the distal nephron, severe renal interstitial edema, and hemorrhage at the corticomedullary junction. The kidneys contained estimated melamine concentrations of 496 to 734 mg/kg wet weight and estimated cyanuric acid concentrations of 487 to 690 mg/kg wet weight. The results demonstrate that the combination of melamine and cyanuric acid is responsible for acute renal failure in cats.

Key Words: Cats  cyanuric acid  feline  kidney  melamine  nephropathy  pet food recall    toxicosis