Determination of dissolution of compound paracetamol and amantadinehydrochloride capsules
XU Jinxing(Hainan Institute for Drug Control,Haikou,Hainan 570102)
Abstract Objective:To establish a HPLC method for the determination of the dissolution of Compound Paracetamol and Amantadine Hydrochloride Capsules. Method: A basket stirring method was applied. ODS column was used ,with the mobile phase of 0.05 mol/L KH2PO4methanol(40∶10) and detective wavelength of 254 nm. Results:The linear range of paracetamol was 0.1108~07756 μg.The average recovery (n=5) was 100.7% (RSD=0.50%). Conclusion:The method is accurate and suitable for the determination of the dissolution of Compound Paracetamoland Amantadine Hydrochloride Capsules.
Key words compound paracetamol and amantadine hydrochloride capsules;paracetamol;dissolution