TS:4 MS的灵敏度降低,如何纠正?
The MS sensitivity has deteriorated. How can I correct it?
There are various possible causes for a deterioration in the sensitivity. The most common are listed below.
1. A problem with the sample. (The target component has transformed, or is volatile and has been lost)
2. A problem with the column (Column is dirty, liquid phase is broken, etc.)
3. A problem with the
gc inlet (Insert is dirty, septum is holed or has been transformed, etc.)
4. A problem with the MSD (Ion source is dirty, mass axis is out of alignment, poor vacuum due to leak, etc.)
5. A connection problem (Sample has escaped due to a leak, length of column emerging from ferrule is incorrect, etc.)
6. A problem with the injection conditions (Split has changed, purge time is too short, etc.)
7. A problem with injection (Metering is inaccurate, septum particles are jammed in needle preventing sample from being taken in, etc.)
8. Fault in Instrument (Fault in the MSD, fault in the
gc flow system)
The MSD can be checked by looking at the autotune results.
Check each of the potential causes and make necessary corrections.
If the problem is still not fixed, contact the Agilent customer service center
灵敏度减弱有很多因素,以下列出较常见的部分:
1.样品的问题(目标组分转化,或者不稳定而丢失)
2.柱子的问题(柱子脏了或者其固定液破坏流失等)
3.
gc进样口的问题(进样口污染,隔垫扎破、变形等)
4 MS的问题(离子源污染,质谱轴脱离校准轴、真空度差)
5.
gc与MS之间的连接问题(由于伸入MS部分的柱子长度不合适而导致样品丢失)
6.进样条件的问题(分流改变,进样切换时间太短)
7.进样针的问题(进样针未正确校准、或者针头被隔垫颗粒堵住影响进样量)
8.仪器自身错误(MS错误、
gc分离错误)
质谱部分的问题可以通过自动调谐的结果检查出来,检查每个可能的潜在因素,并且进行必要的更正。
如果问题依然存在,可以致电服务中心。