![](https://simg.instrument.com.cn/bbs/images/brow/em0815.gif)
Penconazole administered orally to mice and rats was rapidly
absorbed and excreted, predominantly in the urine. Female rats
eliminated more in the urine and less in the faeces than male rats.
Very low residues were found in organs and tissues in both males and
females.
Numerous metabolites were identified in urine and faeces. The
major metabolic pathways involved oxidation of the pentyl side chain
to alcohols and acids with sequential cleavage of the terminal
carbon. As the oxidation products were conjugated, the resulting
metabolic patterns were complex. More polar and conjugated products
were found in female rats. Cleavage of the alkyl bridge between the
two rings led to the formation of 1,2,4-triazole, which was a major
metabolic route in male rats.
自我翻译如下
![](https://simg.instrument.com.cn/bbs/images/brow/em0804.gif)
戊菌唑经口喂向小鼠和大鼠可被迅速吸收和排泄,主要是在尿液中。雌性大鼠更多的通过尿液排除,在粪便中比雄性大鼠排除的要少。在雌性和雄性的器官和组织的残留物非常低。在尿液和粪便可以确定众多的代谢产物。主要代谢途径为参与氧化的戊侧链,以醇类和酸序列卵裂终端的碳。由于氧化产物共轭,由此产生的代谢模式复杂。在雌性大鼠中发现更多的极性和共轭产品。两个环之间的烷基桥断裂,导致形成1,2,4 -三唑,这是雄性大鼠体内戊菌唑的一个重大的代谢路线。