The determination of toxaphene in environmental samples by negative ion electron capture high resolution mass spectrometry
Brian Fowler
Chemosphere
Volume 41, Issue 4, August 2000, Pages 487-492
Abstract:
A method is described for the analysis of toxaphene in environmental samples by high resolution gas chromatography high resolution mass spectrometry in selected ion electron capture negative ion mode. Toxaphene is detected by monitoring [M–Cl]−fragments ions of chlorobornanes (Cl6–Cl10) and chlorobornenes (Cl6–Cl7) using formal ion ratio criteria. The method shows high sensitivity and excellent specificity for the detection of chlorobornanes with negligible interference from of a wide range of common environmental organochlorines including chlordanes, PCBs and PCB-oxygen adducts. The analytical scheme is applicable to sediment and biological tissue samples and typically provide sample detection limits of less than 0.2 ng/g technical toxaphene for a 10 g sample.
Determination of toxaphene in biological samples using high resolution
gc coupled with ion trap MS/MS
Hing Man Chan, Jiping Zhub and Faustinus Yeboah
Chemosphere
Volume 36, Issue 9, April 1998, Pages 2135-2148
Abstract
Toxaphene remains as a pollutant of global concern because of its persistence in the environment. Its complex combination of congeners and the lack of individual standards makes accurate measurement of toxaphene residues in environmental samples a challenge. We have developed a novel method to measure toxaphene in environmental samples using ion trap MS/MS. Adequate sensitivity for analysis of biological samples such as fish and marine mammal blubbers were achieved (around 0.02 ppb to 0.06 ppb for individual congeners and 5.6 ppb for toxaphene mixtures). Accuracy was demonstrated by good recoveries of spiked toxaphene in corn oil samples (102% for toxaphene congeners at 4 ppb and 96% for toxaphene mixture at 139 ppb level). Results of analysis of toxaphene in cod liver oil (NIST SRM 1588) using the MS/MS method compared favorably with the median round robin interlaboratory data. The major advantage of the ion trap MS/MS over the existing methods; electron capture negative ionization mass spectrometer or electron capture detector, is its excellent selectivity. Interference from other organochlorines can virtually be eliminated. Therefore, the developed MS/MS method can be used as a reliable alternative to high resolution mass spectrometer for measurement of toxaphene in environmental samples with relatively low cost instrumentation.
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