主题：【求助】这是一篇文章的摘要，不好懂啊，有能看懂的没？

Bacteria grown in a mixture of multiple sugars will first metabolize a preferred sugar until it is nearly depleted, only
then turning to other carbon sources in the medium. This sharp switching of metabolic preference is characteristic of systems
that optimize fitness. Here we consider the mechanism by which switching can occur in the Escherichia coli phosphotransferase
system (PTS), which regulates the uptake and metabolism of several sugars. Using a model combining the description of fast
biochemical processes and slower genetic regulation, we derive metabolic phase diagrams for the uptake of two PTS sugars,
indicating regions of distinct sugar preference as a function of external sugar concentrations. We then propose a classification
of bacterial phenotypes based on the topology of the metabolic phase diagram, and enumerate the possible topologically
distinct phenotypes that can be achieved through mutations of the PTS. This procedure reveals that there is only one nontrivial
switching phenotype that is insensitive to large changes in biochemical parameters. This phenotype exhibits diauxic growth,
a manifestation of the winner-take-all dynamics enforced by PTS architecture. Winner-take-all behavior is implemented by the
induction of sugar-specific operons, combined with competition between sugars for limited phosphoryl flux. We propose that
flux-limited competition could be a common mechanism for introducing repressive interactions in cellular networks, and we
argue that switching behavior similar to that described here should occur generically in systems that implement such
a mechanism.