10-Oxahexadecanolide
Comprehensive Computer Generated Synopsis
Synonyms
1,8-Dioxacycloheptadecan-9-one CAS EINECS IUPAC
9-[(6-Hydoxyhexyl)oxy]nonanoic acid omicron-lactone
10-Oxahexadecanolide Principal
Oxalide
10-オキサ-ヘキサデカノリド METI
Another Material
CAS Number RIFM ID FEMA EINECS/ELINCS METI/ENCS ECL Registration
1725-01-5 89 217-033-3
EC#217-033-3 (5)-3878 EINECS DSL TSCA
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10-Oxahexadecanolide
is an isomer of 3391-83-1 990 222-225-5 (5)-3879 EINECS DSL TSCA
11-Oxahexadecanolide
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6707-60-4 991 229-755-6 EINECS DSL TSCA
12-Oxahexadecanolide
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RIFM Monograph: 89 (Published 1992: FCT,v30,p99S, Special Issue VIII)
Fragrance Structure-Activity Group Macrocyclic Lactones and Lactides
RIFM Expert Panel Summary Materials Related to Macrocyclic Lactones and Lactides
Formula C15H28O3 Molecular Weight 256.39
SMILES Notation O=C(OCCCCCCOCCCCCCC1)C1
Generic Class (TSCA) Lactones
Description Colorless to pale yellowish viscous liquid; sweet, soft and extremely tenacious, discretely animal-musky odor Arctander Volume II 1969: Colorless viscous liquid. Practically insoluble in water, soluble in alcohol and miscible with all perfume materials. Sweet, soft and extremely tenacious discretely animal musky odor. Although the title material has notes resembling versalide and ethylene brassylate.
Added to RIFM/FEMA Database 1984
Physical Data
Acid Value not more than 1.0 RIFM
Boiling Point (calculated) 380.27 °C EPI Suite
Henry's Law (calculated) 2.043e-005 Pa·m3/mol EPI Suite
Log KOW (calculated) 4.9 EPI Suite
Melting Point (calculated) 46.8 °C EPI Suite
Refractive Index 1.466-1.470 @ 20°C RIFM
Specific Gravity 0.976-0.984 @ 25/25C RIFM
Specific Gravity 0.990 FMA
UV Spectra 1 Takasago
Vapor Pressure (calculated) 0.00000775mmHg @ 20°C EPI Suite 4.0
Vapor Pressure (calculated) 1.58e-005 mm Hg @ 25°C EPI Suite
Water Solubility (calculated) 1.433 mg/L EPI Suite
Natural Occurrence 10-Oxahexadecanolide has apparently not been reported to occur in nature.
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REACH
European EFFA P and I Survey
Range (Metric Tons) Structure Activity Group Survey
1-10 Macrocyclic Lactones and Lactides 2006
Status
Indicative Non-Exhaustive List: Listed
The Industrial Safety and Health Law (Japan): ISHL Number ( (5)-3878)
United Nations Transport Classification Codes: Not regulated
European Hazard Classification Labeling
NC Based on available data, classification and labeling was not considered necessary as per the EFFA Code of Practice.
US OSHA Health Hazard Statements
Irritation Data IR1 Liquid may be irritating to skin and eyes.
Global Harmonized System Hazard Statements
Hazard Category Symbol Signal Word Hazard Statement
SCI 3 Warning H316 Causes mild skin irritation
Precautionary Code Precautionary Statement
P332/313 If skin irritation occurs: Get medical advice/attention
Original FFIDS Volume NEW
12/88
Published FFIDS
Human Health Data
Environmental Data
Other References to 10-Oxahexadecanolide
RIFM - FEMA Database
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Evaluation Priorities
SA 6 28-Jun-10
Structure Alert Components
Rules Topical Effects Systemic Effects Carcinogenic Effects Volume Score Concentration
Level Score
14 0 4 0 2 0
14 Heterocycles except lactones with a ring size >4
Ford R.A., Domeyer B., Easterday O., Maier K. and Middleton J. (2000) Criteria for development of a database for safety evaluation of fragrance ingredients. Regulatory Toxicology and Pharmacology, 31, 166-181.